A groundbreaking study from MedUni Vienna reveals a potential new treatment for psoriasis that restores the function of anti-inflammatory immune cells. Published in the journal ‘Immunity’, this research could lead to a more precise therapy with fewer side effects, marking a significant advancement in chronic inflammatory skin disease management.
The study led by Georg Stary from MedUni Vienna’s Department of Dermatology highlights the role of regulatory T cells (Treg cells) in managing chronic skin inflammation like psoriasis. Treg cells, crucial for controlling immune responses, lose their function in chronic inflammation, exacerbating the disease. Researchers uncovered that this dysfunction is linked to a cellular metabolism malfunction, specifically involving the enzyme SSAT, which regulates molecules essential for immune balance. Increased SSAT production in Treg cells results in a loss of their regulatory capacity, contributing to unchecked inflammation typical of psoriasis.
The discovery of SSAT’s pivotal role offers a novel therapeutic target. In mouse models with psoriasis-like symptoms, inhibiting SSAT successfully restored Treg cell function, breaking the cycle of inflammation. This finding suggests that developing drugs targeting SSAT could provide an effective alternative to current treatments, which often suppress the immune system and increase infection risk.
This research aligns with a broader trend in medical science focusing on precision medicine, which aims to tailor treatments based on individual patient profiles. Experts suggest that targeting specific cellular mechanisms like SSAT could revolutionize treatment approaches not only for psoriasis but also for other chronic inflammatory conditions. The findings underscore the importance of understanding immune regulation in disease management, with potential applications across various inflammatory disorders.
The discovery of SSAT’s role in Treg cell dysfunction opens new avenues for treating psoriasis and potentially other inflammatory diseases. As further studies explore this therapeutic approach, there is optimism for developing treatments with enhanced efficacy and reduced side effects, offering hope to millions affected by these conditions.
Article Source: New Psoriasis Treatment Restores Immune Cell Function | Technology Networks
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